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- by Kaili WangCONCLUSION: In PD patients, constipation is associated with cortical hyperactivation in the prefrontal-premotor areas during the non-dominant hand task. Conversely, FOG correlates with reduced hemodynamic persistence and shortened activation duration […]
- by Ghadir AbbasCONCLUSIONS: STN-DBS outcomes extend beyond global motor improvement and may be shaped by associations spanning the motor, cognitive, and mood domains. Higher NMS baseline burden was associated with poorer mobility […]
- by Gokhan OzkocakGait impairment, postural instability, and freezing of gait are major contributors to mobility limitations in Parkinson's disease (PD). Robot-assisted gait training (RAGT) has emerged as a promising rehabilitation strategy; however, […]
- by Károly Orbán-KisBackground: Advanced Parkinson's disease (aPD) is characterized by motor fluctuations, unpredictable oral absorption, and severe dyskinesias. Levodopa-entacapone-carbidopa intestinal gel (LECIG) is designed to provide dopaminergic stimulation and optimize levodopa bioavailability. […]
- by Chengshuo ZhangCONCLUSION: Exercise interventions may improve freezing-of-gait symptoms, overall motor function, and some aspects of balance performance in patients with PD, although evidence for Mini-BESTest outcomes remains inconclusive. Given the limited […]
- by Jessica E BathINTRODUCTION: Freezing of gait (FOG), a symptom of Parkinson's disease (PD), involves dysfunction across motor, cognitive, and limbic domains. Rehabilitation for PD traditionally emphasizes motor impairments, leaving non-motor FOG contributors […]
- by Matthew LeedomCONCLUSIONS: Resting-state EEG burst dynamics reveal dissociable oscillatory signatures in PD. Low-beta burst timing abnormalities reflect general PD-related motor network dysfunction, whereas theta burst amplitude may relate to FOG severity […]
- by Qibin ZhengCONCLUSION: DTX2 emerges as a key molecular driver of freezing of gait in PD. Pharmacological or genetic suppression of DTX2 stabilizes the Notch2-Nrf2 antioxidant axis, rescuing neurons and restoring motor […]
- by Pramod Kumar PalCONCLUSION: This multicentre survey provides a snapshot of contemporary DBS programming practices for PD in India, highlighting practice variability, increasing adoption of technology-assisted programming, and strong interest in adaptive DBS. […]
- by Demi ZoeteweiIt is currently unclear whether anxiety, cognitive load, or their combination modulates freezing of gait differently and whether people with Parkinson's disease and freezing of gait (freezers) suffer from stronger […]
- by Raquel BarbosaBACKGROUND AND OBJECTIVES: Recent reports have suggested that levodopa exposure may contribute to freezing of gait (FOG), but this relationship remains controversial because of confounding by disease severity and duration. […]
- by Purani BogahawattaScientific interest in mindfulness meditation as complementary therapy for Parkinson's disease (PD) has grown significantly. This systematic review examined mindfulness meditation effects on PD motor, cognitive, falls-related (fear of falling […]
- by Clément DesjardinsCONCLUSIONS: Over 15 years, interindividual therapeutic benefit diverged while axial parkinsonism emerged in nearly all patients. These findings highlight the need for systematic long-term monitoring extending beyond dystonia control after […]
- by Reeree LeeParkinson's disease (PD) is a heterogeneous neurodegenerative disorder with variable long-term outcomes. Blood-based biomarkers for prognostic prediction remain underdeveloped. We aimed to develop a peripheral blood transcriptomic signature for predicting […]
- by Mukta T KilledarParkinson's disease is a progressive neurodegenerative disorder that commonly results in gait dysfunction, balance impairment, postural instability, and reduced functional independence. Freezing gait (FOG) is among the most disabling motor […]
- by Huazhi LiCONCLUSIONS: This study delineates a multilayered network pathology in PD, involving local hyperconnectivity, cortico-subcortical desegregation, and quantitatively verified impairment of large-scale network segregation. These subregion-specific alterations, particularly maladaptive cortico-cerebellar and […]
- by Chae Jung ParkCONCLUSIONS: These findings indicate that larger subcortical WM aPVS volume or higher aPVS count can be an indicator of favorable clinical outcomes in PD.
- by Larissa Karlla R LopesBACKGROUND: Gait disorders are a major cause of disability in Parkinson's disease (PD). Trans-spinal magnetic stimulation (TsMS) shows therapeutic potential, and treadmill training (TT) is widely used; however, their combined […]
- by Georg EbersbachIn addition to response fluctuations caused by the pharmacokinetics of dopamine replacement medication, temporal variation in the expression and severity of motor and non-motor symptoms, which is not or only […]
- by Julian MadridINTRODUCTION: Turning is a complex locomotor task that can accentuate gait impairments and precipitate freezing of gait (FOG) in Parkinson's disease (PD). However, gait-derived spatiotemporal parameters during inter-episodic turning remain […]